We are so proud to share with you our last work published in Nature Communications. Here we identified and characterized the family of Cardiac Glycosides as a novel class of senolytic compounds.
The accumulation of senescent cells is characteristic of the aging process and the development of age-related diseases. It has also been seen that certain chemotherapeutic and radiotherapeutic treatments induce senescence in tumor cells, which is related to certain side effects and recurrences.
Our work shows that the specific elimination of these senescent cells can improve the response of cancer patients to current treatments as well as combat age-related diseases.